iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain TLC


TRAM, LAG1 and CLN8 homology domains.

SMART accession number:SM000724
Description:Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.

Pathways containing proteins with TLC domain are shown in BLUE, and edges containing orthologs which have TLC domain are shown in RED.