iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain PKS_TE



SMART accession number:SM000824
Description:Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.

Pathways containing proteins with PKS_TE domain are shown in BLUE, and edges containing orthologs which have PKS_TE domain are shown in RED.