iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain PI3Kc


Phosphoinositide 3-kinase, catalytic domain

SMART accession number:SM000146
Description:Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.

Pathways containing proteins with PI3Kc domain are shown in BLUE, and edges containing orthologs which have PI3Kc domain are shown in RED.