iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain PH


Pleckstrin homology domain.

SMART accession number:SM000233
Description:Domain commonly found in eukaryotic signalling proteins. The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. PH domains have been found to possess inserted domains (such as in PLC gamma, syntrophins) and to be inserted within other domains. Mutations in Brutons tyrosine kinase (Btk) within its PH domain cause X-linked agammaglobulinaemia (XLA) in patients. Point mutations cluster into the positively charged end of the molecule around the predicted binding site for phosphatidylinositol lipids.

Pathways containing proteins with PH domain are shown in BLUE, and edges containing orthologs which have PH domain are shown in RED.