iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain HTTM


Horizontally Transferred TransMembrane Domain

SMART accession number:SM000752
Description:Sequence analysis of vitamin K dependent gamma-carboxylases (VKGC) revealed the presence of a novel domain, HTTM (Horizontally Transferred TransMembrane) in its N-terminus. In contrast to most known domains, HTTM contains four transmembrane regions. Its occurrence in eukaryotes, bacteria and archaea is more likely caused by horizontal gene transfer than by early invention. The conservation of VKGC catalytic sites indicates an enzymatic function also for the other family members.

Pathways containing proteins with HTTM domain are shown in BLUE, and edges containing orthologs which have HTTM domain are shown in RED.