iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain FYVE


Protein present in Fab1, YOTB, Vac1, and EEA1

SMART accession number:SM000064
Description:The FYVE zinc finger is named after four proteins where it was first found: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn2+ ions. The FYVE finger has eight potential zinc coordinating cysteine positions. The FYVE finger is structurally related to the PHD finger and the RING finger. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. The FYVE finger functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is prominent on endosomes. The R+HHC+XCG motif is critical for PI3P binding.

Pathways containing proteins with FYVE domain are shown in BLUE, and edges containing orthologs which have FYVE domain are shown in RED.