iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain CobW_C


Cobalamin synthesis protein cobW C-terminal domain

SMART accession number:SM000833
Description:CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis PUBMED:12869542. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression PUBMED:7765511.

Pathways containing proteins with CobW_C domain are shown in BLUE, and edges containing orthologs which have CobW_C domain are shown in RED.