iPath: Interactive Pathways Explorer
Metabolic pathways map for SMART domain CobW_C
CobW_CCobalamin synthesis protein cobW C-terminal domain |  | |
| SMART accession number: | SM000833 | |
|---|---|---|
| Description: | CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis PUBMED:12869542. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression PUBMED:7765511. | |
Pathways containing proteins with CobW_C domain are shown in BLUE, and edges containing orthologs which have CobW_C domain are shown in RED.
