iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain C2


Protein kinase C conserved region 2 (CalB)

SMART accession number:SM000239
Description:Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotamins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.

Pathways containing proteins with C2 domain are shown in BLUE, and edges containing orthologs which have C2 domain are shown in RED.