iPath: Interactive Pathways Explorer

Metabolic pathways map for SMART domain AICARFT_IMPCHas


AICARFT/IMPCHase bienzyme

SMART accession number:SM000798
Description:This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.

Pathways containing proteins with AICARFT_IMPCHas domain are shown in BLUE, and edges containing orthologs which have AICARFT_IMPCHas domain are shown in RED.